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6948548 
Journal Article 
Pharmacokinetics of single-dose administration of naproxen at 10:00 and 22:00 hours 
Rao, BR; Rambhau, D; Rao, VV 
1993 
Yes 
Chronobiology International
ISSN: 0742-0528
EISSN: 1525-6073 
10 
2 
137-142 
English 
8500190 
The pharmacokinetics of naproxen was studied in 12 healthy male volunteers after a single oral dose of 500 mg at 10:00 and 22:00 h. Ingestion of drug at 22:00 h delayed the occurrence of peak serum levels (p < 0.0212). None of the other pharmacokinetic parameters exhibited any significant diurnal variations.