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6950355 
Journal Article 
A double-blind, randomized comparison of i.v. lorazepam versus midazolam for sedation of ICU patients via a pharmacologic model 
Barr, J; Zomorodi, K; Bertaccini, EJ; Shafer, SL; Geller, E; , 
2001 
1 
Anesthesiology
ISSN: 0003-3022
EISSN: 1528-1175 
English 
11506097 
Benzodiazepines, such as lorazepam and midazolam, are frequently administered to surgical intensive care unit (ICU) patients for postoperative sedation. To date, the pharmacology of lorazepam in critically ill patients has not been described. The aim of the current study was to characterize and compare the pharmacokinetics and pharmacodynamics of lorazepam and midazolam administered as continuous intravenous infusions for postoperative sedation of surgical ICU patients.