Health & Environmental Research Online (HERO)


Print Feedback Export to File
6950552 
Journal Article 
Contribution of midazolam and its 1-hydroxy metabolite to preoperative sedation in children: a pharmacokinetic-pharmacodynamic analysis 
Johnson, TN; Rostami-Hodjegan, A; Goddard, JM; Tanner, MS; Tucker, GT; , 
2002 
Yes 
British Journal of Anaesthesia
ISSN: 0007-0912
EISSN: 1471-6771 
English 
12402721 
Oral midazolam is widely used for preoperative sedation in children. We have studied the pharmacokinetics (PK) of both midazolam and its active 1-hydroxy metabolite and their contributions to sedative effect in 45 children attending for day surgery.