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6950775 
Journal Article 
Medicinal cannabis does not influence the clinical pharmacokinetics of irinotecan and docetaxel 
Engels, FK; de Jong, FA; Sparreboom, A; Mathot, RA; Loos, WJ; Kitzen, JJ; de Bruijn, P; Verweij, J; Mathijssen, RH; , 
2007 
1 
Oncologist
ISSN: 1083-7159
EISSN: 1549-490X 
English 
17405893 
To date, data regarding the potential of cannabinoids to modulate cytochrome P450 isozyme 3A (CYP3A) activity are contradictory. Recently, a standardized medicinal cannabis product was introduced in The Netherlands. We anticipated an increased use of medicinal cannabis concurrent with anticancer drugs, and undertook a drug-interaction study to evaluate the effect of concomitant medicinal cannabis on the pharmacokinetics of irinotecan and docetaxel, both subject to CYP3A-mediated biotransformation.