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6954150 
Journal Article 
Effect of renal clearance and continuous renal replacement therapy on appropriateness of recommended meropenem dosing regimens in critically ill patients with susceptible life-threatening infections 
Burger, R; Guidi, M; Calpini, V; Lamoth, F; Decosterd, L; Robatel, C; Buclin, T; Csajka, C; Marchetti, O; , 
2018 
Yes 
Journal of Antimicrobial Chemotherapy
ISSN: 0305-7453
EISSN: 1460-2091 
English 
30304491 
Meropenem plasma concentration above a pathogen's MIC over the whole dosing interval (100% ƒT>MIC) is a determinant of outcome in severe infections. Significant variability of meropenem pharmacokinetics is reported in ICU patients.