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6967983 
Journal Article 
Kisspeptin as a potential biomarker throughout pregnancy 
Hu, KaiLun; Zhao, H; Yu, Y; Li, R; , 
2019 
1 
European Journal of Obstetrics, Gynecology, and Reproductive Biology
ISSN: 0301-2115
EISSN: 1872-7654 
ELSEVIER 
AMSTERDAM 
261-266 
31344665 
WOS:000486106700045 
Kisspeptins are a family of neuropeptides that are critical for the puberty initiation and female fertility. Plasma or serum kisspeptin is mainly derived from the placenta during pregnancy and plasma kisspeptin levels significantly increase across pregnancy. Plasma kisspeptin levels could be used as a potential biomarker for the detection of miscarriage, pre-eclampsia, gestational trophoblastic neoplasia (GTN), and fetal development. Kisspeptin may also be involved in the process of parturition by stimulating oxytocin secretion during term pregnancy. This review discussed the potential use of kisspeptin as a marker across pregnancy and highlighted the unresolved problems in this area.Tweetable abstract: Plasma kisspeptin levels could be used as a potential biomarker across pregnancy. (C) 2019 Elsevier B.V. All rights reserved.