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Citation
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HERO ID
6975025
Reference Type
Journal Article
Title
Phenotypic and imaging features of FLNA-negative patients with bilateral periventricular nodular heterotopia and epilepsy
Author(s)
Fallil, Z; Pardoe, H; Bachman, R; Cunningham, B; Parulkar, I; Shain, C; Poduri, A; Knowlton, R; Kuzniecky, R; EPGP Investigators
Year
2015
Is Peer Reviewed?
Yes
Journal
Epilepsy & Behavior
ISSN:
1525-5050
Publisher
Elsevier
Volume
51
Issue
Elsevier
Page Numbers
321-327
Language
English
PMID
26340046
DOI
10.1016/j.yebeh.2015.07.041
Web of Science Id
WOS:000362290200050
URL
https://linkinghub.elsevier.com/retrieve/pii/S1525505015004588
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Abstract
PURPOSE: Periventricular nodular heterotopia (PVNH) is a malformation of cortical development due to impaired neuronal migration resulting in the formation of nodular masses of neurons and glial cells in close proximity to the ventricular walls. We report the clinical characteristics of the largest case series of FLNA-negative patients with seizures and bilateral periventricular heterotopia. METHODS: Participants were recruited through the Epilepsy Phenome/Genome Project (EPGP), a multicenter collaborative effort to collect detailed phenotypic data and DNA on a large number of individuals with epilepsy, including a cohort with symptomatic epilepsy related to PVNH. Included subjects had epilepsy, and MRI confirmed bilateral PVNH. Magnetic resonance imaging studies were visually and quantitatively reviewed to investigate the topographic extent of PVNH, symmetry, and laterality. KEY FINDINGS: We analyzed data on 71 patients with bilateral PVNH. The incidence of febrile seizures was 16.6%. There was at least one other family member with epilepsy in 36.9% of this population. Developmental delay was present in 21.8%. Focal onset seizures were the most common type of seizure presentation (79.3%). High heterotopia burden was strongly associated with female gender and trigonal nodular localization. There was no evidence for differences in brain volume between PVNH subjects and controls. No relationship was observed between heterotopic volume and gender, developmental delay, location of PVNH, ventricular or cerebellar abnormalities, laterality of seizure onset, age at seizure onset, and duration of epilepsy. SIGNIFICANCE: A direct correlation was observed between high heterotopia burden, female gender, and trigonal location in this large cohort of FLNA-negative bilateral PVNH patients with epilepsy. Quantitative MRI measurements indicated that this correlation is based on the diffuse nature of the heterotopic nodules rather than on the total volume of abnormal heterotopic tissue.
Keywords
Epilepsy; Epilepsy Phenome/Gcnome Project; Periventricular nodular heterotopia
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