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6975405 
Journal Article 
Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity 
Nikolic, S; Mihajlovic-Lalic, LE; Vidosavljevic, M; Arandelovic, S; Radulovic, S; Grguric-Sipka, S; , 
2019 
Yes 
Journal of Organometallic Chemistry
ISSN: 0022-328X
EISSN: 1872-8561 
ELSEVIER SCIENCE SA 
LAUSANNE 
WOS:000493061500009 
Four mono- (1-4) and four binuclear Ru(II) arene (5-8) complexes have been isolated from the reaction of [Ru(eta(6)-benzene)Cl(mu-Cl)](2) or [Ru(eta(6)-toluene)Cl(mu-Cl)](2) with 2-pyridinecarboxylic acid and 6-fluoro-2-pyridinecarboxylic acid. Their structural characterization included IR and NMR spectroscopy and MS spectrometry. The cytotoxic potential of the compounds has been tested by MTT assay in seven human cancer cell lines: alveolar basal adenocarcinoma (A549), large cell lung carcinoma (HTB177), colorectal carcinoma (HCT116), malignant melanoma (A375), prostate adenocarcinoma (PC3), breast carcinoma (MDA-MB-453), cervix adenocarcinoma (HeLa), and one human non-malignant lung fibroblast cell line (MRC-5). Mononuclear complexes 1 and 3 carrying 2-pyridinecarboxylic acid have displayed moderate antiproliferative effect toward HCT116 and HeLa, slightly better in comparison to their binuclear analogues, 5 and 7. The highest activity and cytoselectivity has been observed 1 as it has reduced viability of HCT116 cells 1.5 times more efficiently (IC50 = 27.5 mu M), than of the MRC-5 cells (IC50 = 41.3 mu M). In contrast to 1 and 3, compounds 2, 4-8 have been found to exhibit lack of cytotoxicity or mild cytotoxicity with IC50 values ranging from 100 to 300 mu M. (C) 2019 Elsevier B.V. All rights reserved.