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6975836 
Journal Article 
Syntheses of Novel Tetrasubstituted Thiophenes from Benzene-1,2-Diamines, Ethyl Bromopyruvate, Malononitrile, and Aryl Isothiocyanates 
Piltan, M; , 
2020 
1 
Polycyclic Aromatic Compounds
ISSN: 1040-6638
EISSN: 1563-5333 
TAYLOR & FRANCIS LTD 
ABINGDON 
41 
10 
2103-2109 
WOS:000506543000001 
Synthesis of highly functionalized tetrasubstituted thiophenes has been reported involving 3-(bromomethyl)quinoxalin-2(1H)-ones as activated halomethylene compounds precursors. Thus sequential base mediated condensation of readily available malononitrile with aryl isothiocyanates followed by S-alkylation of the resulting enethiolate salts with 3-(bromomethyl)quinoxalin-2(1H)-one compounds and concurrent intramolecular enamine type condensation of S-alkylated compounds affords substituted thiophenes in excellent yields.