Repetitive Aerosol Exposure Promotes Cavitary Tuberculosis and Enables Screening for Targeted Inhibitors of Extensive Lung Destruction | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

6985241

Reference Type

Journal Article

Title

Repetitive Aerosol Exposure Promotes Cavitary Tuberculosis and Enables Screening for Targeted Inhibitors of Extensive Lung Destruction

Author(s)

Urbanowski, ME; Ihms, EA; Bigelow, K; Kubler, A; Elkington, PT; Bishai, WR

Year

2018

Is Peer Reviewed?

Yes

Journal

Journal of Infectious Diseases
ISSN: 0022-1899
EISSN: 1537-6613

Volume

218

Issue

Page Numbers

53-63

Language

English

PMID

29554286

DOI

10.1093/infdis/jiy127

Web of Science Id

WOS:000434930900008

Abstract

Cavitation is a serious consequence of tuberculosis. We tested the hypothesis that repetitive exposure to the same total bacterial burden of Mycobacterium tuberculosis drives greater lung destruction than a single exposure. We also tested whether inhibition of endogenous matrix metalloproteinase-1 (MMP-1) may inhibit cavitation during tuberculosis.

Keywords

tuberculosis; cavity; matrix metalloproteinase; rabbit; cipemastat