Prime-pull vaccination with a plant-derived virus-like particle influenza vaccine elicits a broad immune response and protects aged mice from death and frailty after challenge
Hodgins, B; Pillet, S; Landry, N; Ward, BJ
| HERO ID | 6986322 |
|---|---|
| In Press | No |
| Year | 2019 |
| Title | Prime-pull vaccination with a plant-derived virus-like particle influenza vaccine elicits a broad immune response and protects aged mice from death and frailty after challenge |
| Authors | Hodgins, B; Pillet, S; Landry, N; Ward, BJ |
| Journal | Immunity & Ageing |
| Volume | 16 |
| Issue | 1 |
| Abstract | Administered intramuscularly (IM), plant-derived, virus-like-particle (VLP) vaccines based on the influenza hemagglutinin (HA) protein elicit both humoral and cellular responses that can protect aged mice from lethal challenge. Unlike split virus vaccines, VLPs can be administered by different routes including intranasally (IN). We evaluated novel vaccine strategies such as prime-pull (IM boosted by IN) and multi-modality vaccination (IM and IN given simultaneously). We wished to determine if these approaches would provide better quality protection in old mice after less severe (borderline-lethal) challenge (ie: immunogenicity, frailty and survival). |
| Doi | 10.1186/s12979-019-0167-6 |
| Pmid | 31700523 |
| Wosid | WOS:000494276500001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Aged mouse model; Frailty; Influenza vaccines; Virus-like particles; Multi-modality; Prime-pull |