Prime-pull vaccination with a plant-derived virus-like particle influenza vaccine elicits a broad immune response and protects aged mice from death and frailty after challenge | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

6986322

Reference Type

Journal Article

Title

Prime-pull vaccination with a plant-derived virus-like particle influenza vaccine elicits a broad immune response and protects aged mice from death and frailty after challenge

Author(s)

Hodgins, B; Pillet, S; Landry, N; Ward, BJ

Year

2019

Is Peer Reviewed?

Yes

Journal

Immunity & Ageing
ISSN: 1742-4933

Volume

Issue

Language

English

PMID

31700523

DOI

10.1186/s12979-019-0167-6

Web of Science Id

WOS:000494276500001

Abstract

Administered intramuscularly (IM), plant-derived, virus-like-particle (VLP) vaccines based on the influenza hemagglutinin (HA) protein elicit both humoral and cellular responses that can protect aged mice from lethal challenge. Unlike split virus vaccines, VLPs can be administered by different routes including intranasally (IN). We evaluated novel vaccine strategies such as prime-pull (IM boosted by IN) and multi-modality vaccination (IM and IN given simultaneously). We wished to determine if these approaches would provide better quality protection in old mice after less severe (borderline-lethal) challenge (ie: immunogenicity, frailty and survival).

Keywords

Aged mouse model; Frailty; Influenza vaccines; Virus-like particles; Multi-modality; Prime-pull