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6987046 
Journal Article 
Understanding the Immunologic Characteristics of Neurologic Manifestations of SARS-CoV-2 and Potential Immunological Mechanisms 
Mohammadi, S; Moosaie, F; Aarabi, MH 
2020 
1 
Molecular Neurobiology
ISSN: 0893-7648 
57 
12 
5263-5275 
English 
32869183 
WOS:000564497500002 
Similar to its predecessors, coronavirus disease 2019 (COVID-19) exhibits neurotrophic properties, which lead to progression of neurologic sequelae. Besides direct viral invasion to the central nervous system (CNS), indirect CNS involvement through viral-mediated immune response is plausible. Aberrant immune pathways such as extreme release of cytokines (cytokine storm), autoimmunity mediated by cross-reactivity between CNS components and viral particles, and microglial activation propagate CNS damage in these patients. Here, we review the currently available evidence to discuss the plausible immunologic pathways that may contribute to the development of COVID-19 neurological complications, namely Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis, Guillain-Barre syndrome, seizure, and brainstem involvement. 
Cytokines; Coronavirus disease 2019; Immunologic pathways; Neurological complications; Central nervous system; SARS-CoV-2