Health & Environmental Research Online (HERO)


Print Feedback Export to File
6987700 
Journal Article 
Review 
Emerging Concepts and Technologies in Vaccine Development 
Brisse, M; Vrba, SM; Kirk, N; Liang, Y; Ly, H 
2020 
1 
Frontiers in Immunology
EISSN: 1664-3224 
11 
583077 
English 
33101309 
WOS:000579399400001 
Despite the success of vaccination to greatly mitigate or eliminate threat of diseases caused by pathogens, there are still known diseases and emerging pathogens for which the development of successful vaccines against them is inherently difficult. In addition, vaccine development for people with compromised immunity and other pre-existing medical conditions has remained a major challenge. Besides the traditional inactivated or live attenuated, virus-vectored and subunit vaccines, emerging non-viral vaccine technologies, such as viral-like particle and nanoparticle vaccines, DNA/RNA vaccines, and rational vaccine design, offer innovative approaches to address existing challenges of vaccine development. They have also significantly advanced our understanding of vaccine immunology and can guide future vaccine development for many diseases, including rapidly emerging infectious diseases, such as COVID-19, and diseases that have not traditionally been addressed by vaccination, such as cancers and substance abuse. This review provides an integrative discussion of new non-viral vaccine development technologies and their use to address the most fundamental and ongoing challenges of vaccine development. 
non-viral DNA-RNA vaccines; nanoparticle vaccines; virus-like particle vaccines; cancer vaccines; substance abuse; noncommunicable disease; infectious disease; COVID19