US EPA

6865703 

Journal Article 

Vitamin A and carotenoid toxicity 

Blomhoff, R 

2001 

Yes 

Food and Nutrition Bulletin
ISSN: 0379-5721 

22 

3 

320-334 

English 

10.1177/156482650102200309 

Large differences in time and dose needed to induce hypervitaminosis A have been observed. High doses of vitamin A in food and oily solutions are well tolerated, whereas emulsified preparations have higher toxicity. Chronic hypervitaminosis seems to be induced following daily doses of 300,000 to 600,000 IU of vitamin A (90–180 mg of retinol) in oily preparations for many months or years, whereas teratogenicity may be induced by daily doses as low as 40,000 IU of vitamin A (12 mg of retinol) in oil during the first trimester. for the provitamin A, β-carotene, serious adverse effects have been reported in large-scale prospective randomized trials: four years of supplementation with 20 to 30 mg β-carotene per day was associated with increased risk of lung cancer and cardiovascular disease among smokers and workers exposed to asbestos. These results strongly suggest that high doses of β-carotene should not be recommended for any group until the safety of such doses can be established.