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6990931 
Journal Article 
Morphometeric study of primary sensory neurons following surgical repair of sciatic nerve 
Atlasi, MAli; Mehdizadeh, M; Bahadori, MH; Joghataei, MT; , 
2007 
1 
Pakistan Journal of Medical Sciences
ISSN: 1682-024X
EISSN: 1681-715X 
PROFESSIONAL MEDICAL PUBLICATIONS 
SADDAR 
366-369 
WOS:000254518400015 
Objective: Peripheral nerve transection causes neuonal cell death. Effects of surgical nerve repair on survival of primary sensory neurons was to be studied.Methodology: This is a morphometeric study of dorsal root ganglion neurons of adult rats by Hoechst staining conducted at Neuroscience laboratory and Cellular and Molecular Center, Medical faculty, Iran University of Medical Sciences. Models of direct epineurial suture and using of nerve guidance channel of polyvinilydin flourid (PVDF) were used and neuronal number and volume of dorsal root ganglion of L5 were evaluated by morphometeric method.Results: Direct epineurial suture technique decreased sensory neuronal loss and both direct epineurial suture Et using of nerve guidance channel decreased reduction of the ganglion volume.Conclusion: Present study showed distal segment of peripheral nerve is essential for neuronal survival, but surgical nerve repair could not completely prevent from neuronal cell death.