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6992585 
Journal Article 
Chloroform Fraction of Methanolic Extract of Seeds of Annona muricata Induce S Phase Arrest and ROS Dependent Caspase Activated Mitochondria Mediated Apoptosis in Triple Negative Breast Cancer 
George, AJ; Kariyil, BJ; Ayyappan, UPT; Gopalakrishnan, A; , 
2020 
1 
Anti-Cancer Agents in Medicinal Chemistry
ISSN: 1871-5206
EISSN: 1875-5992 
21 
10 
1250-1265 
English 
32951586 
WOS:000631834400005 
Triple negative breast cancers (TNBCs) are having high morbidity and shorter survival rate in the population. These types of cancers are having high aggressiveness, lymphatic invasion and absence of receptors. The treatment options for these types of cancers are also scarce. Several studies have been conducted to investigate the effectiveness of seeds of Annona muricata for its anti cancer activities in various cancer cell lines such as lung A549, breast MCF7, colon HT-29, oral KB and human hepatoma cell lines. But works related to its anticancer effect and mechanism of action in TNBCs has not been elucidated. 
Index Medicus 
IRIS
• Chloroform Combined (current)
     Chloroform (current)
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