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6993683 
Journal Article 
CARDIAC-OUTPUT DURING LIQUID (PERFLUOROCARBON) BREATHING IN NEWBORN PIGLETS 
Curtis, SE; Fuhrman, BP; Howland, DF; Defrancisis, M; Motoyama, EK 
1991 
Yes 
Critical Care Medicine
ISSN: 0090-3493
EISSN: 1530-0293 
19 
2 
225-230 
English 
1989758 
WOS:A1991EW99000019 
Liquid ventilation using perfluorocarbons is a new technique for ventilation of infants with restrictive lung disease. However, this method of ventilation has been shown to impair cardiac output (Qt) in several animal species, casting doubt as to its feasibility. This study tested whether Qt could be maintained during liquid breathing by intravascular volume expansion. Seven piglets were carefully hydrated, instrumented for continuous Qt measurement, and subjected to 2 hr of liquid breathing. PaCO2 was maintained at 40 to 50 torr (5.3 to 6.7 kPa), and PaO2 greater than 80 torr (greater than 10.7 kPa). Additional colloid was given during liquid breathing if Qt decreased to less than 90% of preliquid breathing values. 
CARDIAC OUTPUT; PERFLUOROCARBON; PIGLET; COLLOID; OXYGEN CONSUMPTION; MECHANICAL VENTILATION; VASCULAR RESISTANCE; POSITIVE PRESSURE RESPIRATION; BREATHING; OXYGEN