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6995165 
Journal Article 
Immune response to vaccine adjuvants during the first year of life 
Levy, O; Goriely, S; Kollmann, TR 
2013 
1 
Vaccine
ISSN: 0264-410X
EISSN: 1873-2518 
31 
21 
2500-2505 
WOS:000320143200004 
Subunit vaccine formulations often include adjuvants that primarily stimulate innate immune cells. While young infants represent the major target population for vaccination, effective immunization in this age group remains a challenge. Many parameters of innate immune responses differ quantitatively and qualitatively from newborns to infants and adults, revealing a highly regulated developmental program. Herein, we discuss the potential implications of innate immune ontogeny for the activity of adjuvants contained in licensed infant vaccines, as well as future directions for rational design of adjuvanted vaccines for this age group. (C) 2012 Elsevier Ltd. All rights reserved. 
Adjuvants; Innate immunity; Vaccines; Newborn; Infant; Immunization