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6996396 
Journal Article 
Genomic adaptation of the ISA virus to Salmo salar codon usage 
Vijayakrishnan, S; Loney, C; Tello, M; Vergara, F; Spencer, E 
2013 
1 
Virology Journal
ISSN: 1743-422X 
10 
English 
23829271 
WOS:000321438800001 
The ISA virus (ISAV) is an Orthomyxovirus whose genome encodes for at least 10 proteins. Low protein identity and lack of genetic tools have hampered the study of the molecular mechanism behind its virulence. It has been shown that viral codon usage controls several processes such as translational efficiency, folding, tuning of protein expression, antigenicity and virulence. Despite this, the possible role that adaptation to host codon usage plays in virulence and viral evolution has not been studied in ISAV.