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6996991 
Journal Article 
Structure and assembly of the influenza A virus ribonucleoprotein complex 
Zheng, W; Tao, YJ; , 
2013 
Yes 
FEBS Letters
ISSN: 0014-5793
EISSN: 1873-3468 
WILEY 
HOBOKEN 
1206-1214 
23499938 
WOS:000317188700027 
The genome of influenza A viruses consists of eight segments of single-stranded, negative-sense RNA that are encapsidated as individual rod-shaped ribonucleoprotein complexes (RNPs). Each RNP contains a viral RNA, a viral polymerase and multiple copies of the viral nucleoprotein (NP). Influenza A virus RNPs play important roles during virus infection by directing viral RNA replication and transcription, intracellular transport of the viral RNA, gene reassortment as well as viral genome packaging into progeny particles. As a unique genomic entity, the influenza A virus RNP has been extensively studied since the 1960s. Recently, exciting progress has been made in studying the RNP structure and its assembly, leading to a better understanding of the structural basis of various RNP functions. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.