Inhibition of deubiquitination by PR-619 induces apoptosis and autophagy via ubi-protein aggregation-activated ER stress in oesophageal squamous cell carcinoma | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

6997713

Reference Type

Journal Article

Title

Inhibition of deubiquitination by PR-619 induces apoptosis and autophagy via ubi-protein aggregation-activated ER stress in oesophageal squamous cell carcinoma

Author(s)

Wang, L; Li, M; Sha, B; Hu, X; Sun, Y; Zhu, M; Xu, Y; Li, P; Wang, Y; Guo, Y; Li, J; Shi, J; Li, P; Hu, T; Chen, P; ,

Year

2020

Is Peer Reviewed?

Yes

Journal

Cell Proliferation
ISSN: 0960-7722
EISSN: 1365-2184

Publisher

WILEY

Location

HOBOKEN

Language

English

PMID

33129231

DOI

10.1111/cpr.12919

Web of Science Id

WOS:000582979200001

Abstract

Targeting the deubiquitinases (DUBs) has become a promising avenue for anti-cancer drug development. However, the effect and mechanism of pan-DUB inhibitor, PR-619, on oesophageal squamous cell carcinoma (ESCC) cells remain to be investigated.