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7000737 
Journal Article 
The magnetofection method: Using magnetic force to enhance gene delivery 
Plank, C; Schillinger, U; Scherer, F; Bergemann, C; Remy, JS; Krotz, F; Anton, M; Lausier, J; Rosenecker, J; , 
2003 
Yes 
Biological Chemistry
ISSN: 1431-6730
EISSN: 1437-4315 
WALTER DE GRUYTER GMBH 
BERLIN 
737-747 
12817470 
WOS:000183421000006 
In order to enhance and target gene delivery we have previously established a novel method, termed magnetofection, which uses magnetic force acting on gene vectors that are associated with magnetic particles. Here we review the benefits, the mechanism and the potential of the method with regard to overcoming physical limitations to gene delivery. Magnetic particle chemistry and physics are discussed, followed by a detailed presentation of vector formulation and optimization work. While magnetofection does not necessarily improve the overall performance of any given standard gene transfer method in vitro, its major potential lies in the extraordinarily rapid and efficient transfection at low vector doses and the possibility of remotely controlled vector targeting in vivo.