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7001060 
Journal Article 
Virus-like particles: Passport to immune recognition 
Grgacic, EVL; Anderson, DA; , 
2006 
1 
Methods
ISSN: 1046-2023
EISSN: 1095-9130 
ACADEMIC PRESS INC ELSEVIER SCIENCE 
SAN DIEGO 
60-65 
16997714 
WOS:000241463900007 
Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid proteins from many viruses. In many cases such VLPs have structural characteristics and antigenicity similar to the parental virus, and some have already proven successful as vaccines against the cognate virus infection. The structural components of some VLPs have also proven amenable to the insertion or fusion of foreign antigenic sequences, allowing the production of chimeric VLPs exposing the foreign antigen on their surface. Other VLPs have been used as carriers for foreign antigens, including non-protein antigens, via chemical conjugation. This review outlines some of the advantages, disadvantages, and technical considerations for the use of a wide range of VLP systems in vaccine development. (c) 2006 Elsevier Inc. All rights reserved.