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7002444 
Journal Article 
A toxicokinetic framework and analysis tool for interpreting OECD-305 dietary bioaccumulation tests 
Gobas, FAPC; Lee, YS; Lo, JC; Parkerton, TF; Letinski, DJ 
2019 
Yes 
Environmental Toxicology and Chemistry
ISSN: 0730-7268
EISSN: 1552-8618 
39 
1 
171-188 
English 
31546284 
WOS:000499547500001 
The Organisation for Economic Co‐operation and Development guideline 305 for bioaccumulation testing in fish includes the option to conduct a dietary test for assessing a chemical's bioaccumulation behavior. However, the one‐compartment toxicokinetic model that is used in the guidelines to analyze the results from dietary bioaccumulation tests is not consistent with the current state of the science, experimental practices, and information needs for bioaccumulation and risk assessment. The present study presents 1) a 2‐compartment toxicokinetic modeling framework for describing the bioaccumulation of neutral hydrophobic organic chemicals in fish and 2) an associated toxicokinetic analysis tool (absorption, distribution, metabolism, and excretion [ADME] B calculator) for the analysis and interpretation of dietary bioaccumulation test data from OECD‐305 dietary tests. The model framework and ADME‐B calculator are illustrated by analysis of fish dietary bioaccumulation test data for 238 substances representing different structural classes and susceptibilities to biotransformation. The ADME of the chemicals is determined from dietary bioaccumulation tests and bioconcentration factors, biomagnification factors, and somatic and intestinal biotransformation rates. The 2‐compartment fish toxicokinetic model can account for the effect of the exposure pathway on bioaccumulation, which the one‐compartment model cannot. This insight is important for applying a weight‐of‐evidence approach to bioaccumulation assessment where information from aqueous and dietary test endpoints can be integrated to improve the evaluation of a chemical's bioaccumulation potential. 
bioaccumulation; bioconcentration; biomagnification; biotransformation; trophic magnification