Health & Environmental Research Online (HERO)


Print Feedback Export to File
7015405 
Journal Article 
Early non-response in patients with severe depression: escitalopram up-titration versus switch to duloxetine 
Bose, A; Tsai, J; Li, D; , 
2012 
Yes 
Clinical Drug Investigation
ISSN: 1173-2563 
ADIS INT LTD 
AUCKLAND 
32 
6 
373-385 
English 
22559255 
WOS:000304727700002 
Comparative evidence for second-step treatment strategies in severe depression is scarce. Up-titrating a well tolerated selective serotonin reuptake inhibitor (SSRI) versus switching to a serotonin norepinephrine reuptake inhibitor (SNRI) after initial SSRI non-response are possible treatment options. It is often unclear whether relevant tolerability and efficacy differences exist between SSRI up-titration versus switch to an SNRI.