Faur, DM; Moldovan, M; Prodan, D; Aldea, C; Deleanu, D; Bulata, B; Caliment, A; Borzan, C; ,
Chronic kidney disease (CKD) represents a progressing and life-threatening pathology which produces a series of changes in the bio humoral parameters. Some of the changes that develop in CKD includes modified levels of minerals and trace elements such as iron, nickel, selenium, magnesium, zinc, copper, aluminium. In a proper concentration, those are playing an important physiological role in healthy organisms but in CKD because of the reduced glomerular filtration, acid-base imbalance, and hemodialysis, modified levels of trace elements might produce alteration in metabolism, enzymes activity and also disturbings in membrane potential imbalance, which may induce cardiac arithmia and sudden death. The purpose of this study is to assess trace elements in the urine of patients with chronic renal failure who undergo dialysis and healthy participants, compare the groups and correlate the values with the rural and urban origin and also the source of water used for consumption. This case control study has pediatric patients with CKD who undergo dialisys and healthy children as control group. The urine samples were collected from Pediatric Nephrology Department, using standard procedures. Concentrations of minerals and trace elements (iron, nickel, selenium, magnesium, zinc, copper, aluminium) were determined by an inductively coupled plasma optical emission spectroscopy - Optima 2100. We observed differences in the levels of trace elements determined in urine samples, between healthy children and those with renal insufficiency and also higher levels of some trace elements in the patients who consume public water.