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7020071 
Journal Article 
Review 
Applications for Transition-Metal Chemistry in Contrast-Enhanced Magnetic Resonance Imaging 
Gupta, A; Caravan, P; Price, WS; Platas-Iglesias, C; Gale, EM; , 
2020 
Yes 
Inorganic Chemistry
ISSN: 0020-1669
EISSN: 1520-510X 
AMER CHEMICAL SOC 
WASHINGTON 
59 
10 
6648-6678 
English 
32367714 
WOS:000535304900002 
Contrast-enhanced magnetic resonance imaging (MRI) is an indispensable tool for diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI contrast agents have emerged in recent years. For patients suffering from severe renal impairment, there is an important unmet medical need to perform contrast-enhanced MRI without gadolinium. There are also concerns over the long-term effects of retained gadolinium within the general patient population. Demand for gadolinium-free MRI contrast agents is driving a new wave of inorganic chemistry innovation as researchers explore paramagnetic transition-metal complexes as potential alternatives. Furthermore, advances in personalized care making use of molecular-level information have motivated inorganic chemists to develop MRI contrast agents that can detect pathologic changes at the molecular level. Recent studies have highlighted how reaction-based modulation of transition- metal paramagnetism offers a highly effective mechanism to achieve MRI contrast enhancement that is specific to biochemical processes. This Viewpoint highlights how recent advances in transition-metal chemistry are leading the way for a new generation of MRI contrast agents.