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7037303 
Journal Article 
The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection 
Beddingfield, BJ; Iwanaga, N; Chapagain, PP; Zheng, W; Roy, CJ; Hu, TY; Kolls, JK; Bix, GJ; , 
2020 
English 
33102950 
Many efforts to design and screen therapeutics for the current severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic have focused on inhibiting viral host cell entry by disrupting ACE2 binding with the SARS-CoV-2 spike protein. This work focuses on the potential to inhibit SARS-CoV-2 entry through a hypothesized α5β1 integrin-based mechanism, and indicates that inhibiting the spike protein interaction with α5β1 integrin (+/- ACE2), and the interaction between α5β1 integrin and ACE2 using a novel molecule ATN-161 represents a promising approach to treat COVID-19.