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7042525 
Journal Article 
The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex 
Randal, M; Kossiakoff, AA; , 
2001 
1 
Structure
ISSN: 0969-2126 
English 
11250200 
Interferon-gamma (IFN-gamma) is a homodimeric cytokine that exerts its various activities by inducing the aggregation of two different receptors. The alpha chain receptor (IFN-gammaRalpha) is a high affinity receptor that binds to IFN-gamma in a symmetric bivalent manner to form a stable, intermediate 1:2 complex. This intermediate forms a binding template for the subsequent binding of two copies of the second receptor, beta chain receptor (IFN-gammaRbeta), producing the active 1:2:2 signaling complex.