Analgesic Efficacy of an Acetaminophen/Ibuprofen Fixed-dose Combination in Moderate to Severe Postoperative Dental Pain: A Randomized, Double-blind, Parallel-group, Placebo-controlled Trial | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7044062

Reference Type

Journal Article

Title

Analgesic Efficacy of an Acetaminophen/Ibuprofen Fixed-dose Combination in Moderate to Severe Postoperative Dental Pain: A Randomized, Double-blind, Parallel-group, Placebo-controlled Trial

Author(s)

Daniels, SE; Atkinson, HC; Stanescu, I; Frampton, C; ,

Year

2018

Is Peer Reviewed?

Yes

Journal

Clinical Therapeutics
ISSN: 0149-2918

Publisher

ELSEVIER

Location

BRIDGEWATER

Page Numbers

1765-1776

Language

English

PMID

30245281

DOI

10.1016/j.clinthera.2018.08.019

Web of Science Id

WOS:000448760900017

Abstract

Acute pain is a significant burden to the individual and to society. There is a clear need for a pain medication that provides improved analgesia over common analgesics, without compromising tolerability. The goal of this study was to determine the efficacy of a new fixed-dose combination of acetaminophen 975 mg and ibuprofen 292.5 mg (FDC 975/292.5) relative to acetaminophen or ibuprofen monotherapy, or placebo.