US EPA

7047190 

Journal Article 

COMPARISON OF CLINICAL EFFECT OF FIXED-DOSE COMBINATION FOR TUBERCULOSIS TREATMENT IN HEBEI AND JILIN PROVINCE, CHINA 

Yu, B; Zhu, X; Zhou, Lin; Yu, Q; Zhang, T; Zhang, P; Sun, Y; Cao, B; Rao, W; Kang, G; Li, R; Kang, Qi; , 

2020 

1 

Acta Medica Mediterranea
ISSN: 0393-6384
EISSN: 2283-9720 

CARBONE EDITORE 

PALERMO 

779-785 

10.19193/0393-6384_2020_2_120 

WOS:000526121600005 

Introduction: Most of the high tuberculosis (TB) burden countries around the world have used Fixed-dose combination (FDC). However, there are few studies on the dose and dosage form of FDC in the Chinese population. We aimed to evaluate the clinical effect of FDC in anti-tuberculosis and choose an appropriate treatment regime for Chinese population.Materials and methods: Between July 1, 2011 and December 31, 2012, the newly diagnosed pulmonary TB patients from Hebei Province (n=1227) and Jilin Province (n=1130) were included in the study. A total of 2357 participants were given FDC treatment for six months (intensive phase-2 months of isoniazid, rifampicin, ethambutol and pyrazinamide; continuation phase-4months of rifampicin and isoniazid). The two provinces used two different schemes from the dose of drug. These schemes were assessed the drug compliance of tuberculosis patients, drug substitution and ADRs.Results: In the statistical analysis, the curing rate was 94.81% (5121540) meanwhile, successfully completed the treatment and the treatment success rate was accounted for 93.4% (114611227) of all patients in Hebei; the curing rate was 92.49% (3451373). Meanwhile, successfully completed the treatment and the treatment success rate was accounted for 98.1%(110911130) of all patients in Jilin. The cure rate in Hebei Province was superior to Jilin Province. However, the effective rate in Hebei Province was inferior to Jilin Province at the end of chemotherapy for TB.Conclusion: This study found that the curing treatment for pulmonary TB patients in Hebei province was superior to AIM province. Whereas the analysis showed that the ADRs of Jilin province was inferior to the ADRs of Hebei Province. The anti-tuberculosis effect of FDC should be further studied in large samples in the future.