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HERO ID
7053367
Reference Type
Journal Article
Title
Does Early Childhood Vaccination Protect Against COVID-19?
Author(s)
Sidiq, KR; Sabir, DK; Ali, SM; Kodzius, R; ,
Year
2020
Publisher
FRONTIERS MEDIA SA
Location
LAUSANNE
PMID
32582766
DOI
10.3389/fmolb.2020.00120
Web of Science Id
WOS:000543195500001
Abstract
The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans. The published data show that children, unlike adults, are less susceptible to contracting the disease. This article aims at understanding why children constitute a minor group among hospitalized COVID-19 patients. Here, we hypothesize that the measles, mumps, and rubella (MMR) vaccine could provide a broad neutralizing antibody against numbers of diseases, including COVID-19. Our hypothesis is based on the 30 amino acid sequence homology between the SARS-CoV-2 Spike (S) glycoprotein (PDB: 6VSB) of both the measles virus fusion (F1) glycoprotein (PDB: 5YXW_B) and the rubella virus envelope (E1) glycoprotein (PDB: 4ADG_A). Computational analysis of the homologous region detected the sequence as antigenic epitopes in both measles and rubella. Therefore, we believe that humoral immunity, created through the MMR vaccination, provides children with advantageous protection against COVID-19 as well, however, an experimental analysis is required.
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