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HERO ID
7053834
Reference Type
Journal Article
Title
Growth-Inhibiting, Bactericidal, Antibiofilm, and Urease Inhibitory Activities of Hibiscus rosa sinensis L. Flower Constituents toward Antibiotic Sensitive- and Resistant-Strains of Helicobacter pylori
Author(s)
Hieu Tran Trung; Hoa Truong Thi Huynh; Linh Nguyen Thi Thuy; Hoang Nguyen Van Minh; My-Nuong Thi Nguyen; My Ngan Luong Thi; ,
Year
2020
Journal
ACS Omega
EISSN:
2470-1343
Publisher
AMER CHEMICAL SOC
Location
WASHINGTON
Page Numbers
20080-20089
PMID
32832762
DOI
10.1021/acsomega.0c01640
Web of Science Id
WOS:000563015100017
Abstract
The aim of the present study was to assess antimicrobial effects of naringenin (NRG), luteolin (LUT), myricetin (MCT), and protocatechuic acid (PCA) identified in a Hibiscus rosa sinensis flower against two reference strains and five clinical isolates of Helicobacter pylon. NRG displayed the most growth inhibitory and bactericidal activities to seven bacterial strains including six strains resistant to one or several antibiotics, azithromycin (MIC, 16-32 mg/L), erythromycin (MIC, 32 mg/L), levofloxacin (MIC, 32 mg/L), and/or metronidazole (24-64 mg/L), followed by LUT and MCT, while PCA showed weak activities toward the strains. These constituents had similar antibacterial activities toward the seven tested strains suggesting that these constituents and the antibiotics do not have a common mechanism of anti-H. pylon activity. NRG, LUT, and MCT resulted in a high percentage of coccoid forms of H. pylon. NRG exhibited the highest anti-biofilm formation activity. MCT produced the strongest inhibition of urease activity followed by LUT and PCA, whereas the activity of NRG was similar to standard inhibitor thiourea. The four constituents had no significant toxicity to human cell lines. A global attempt to decrease utilization of antibiotics justifies the need for further research on H. rosa sinensis derived materials containing NRG, LUT, MCT, and PCA as potential products or lead compounds for the prevention or treatment of diseases caused by H. pylon infection.
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