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7056499 
Journal Article 
Molecular mechanism of growth hormone action 
Carter-Su, C; Schwartz, J; Smit, LS; , 
1996 
Yes 
Annual Review of Physiology
ISSN: 0066-4278
EISSN: 1545-1585 
ANNUAL REVIEWS INC 
PALO ALTO 
187-207 
English 
8815791 
WOS:A1996UB98400010 
Although the ability of growth hormone (GH) to stimulate body growth and regulate metabolism has been recognized for many years, only recently has insight been gained into the molecular mechanisms by which binding of GH to its receptor (GHR) elicits its diverse effects. This review provides an overview of what is currently known about the molecular mechanisms of GH action. The model presented is one in which GH binding to two GHRs causes dimerization of GHR, activation of the GHR-associated JAK2 tyrosine kinase, and tyrosyl phosphorylation of both JAK2 and GHR. These events recruit and/or activate a variety of signaling molecules, including MAP kinases, insulin receptor substrates, phosphatidylinositol 3' phosphate kinase, diacylglycerol, protein kinase C, intracellular calcium, and Stat transcription factors. These signaling molecules contribute to the GH-induced changes in enzymatic activity, transport function, and gene expression that ultimately culminate in changes in growth and metabolism.