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7060064 
Journal Article 
Paxillin and focal adhesion signalling 
Turner, CE; , 
2000 
1 
Nature Cell Biology
ISSN: 1465-7392
EISSN: 1476-4679 
English 
11146675 
To facilitate a rapid response to environmental change, cells use scaffolding - or adaptor - proteins to recruit key components of their signal-transduction machinery to specific subcellular locations. Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton. Here it provides a platform for the integration and processing of adhesion- and growth factor-related signals.