Health & Environmental Research Online (HERO)


Print Feedback Export to File
7060127 
Journal Article 
A cytokine-mediated link between innate immunity, inflammation, and cancer 
Lin, WW; Karin, M; , 
2007 
Yes 
Journal of Clinical Investigation
ISSN: 0021-9738
EISSN: 1558-8238 
AMER SOC CLINICAL INVESTIGATION INC 
ANN ARBOR 
1175-1183 
English 
17476347 
WOS:000246347000008 
It has been established that cancer can be promoted and/or exacerbated by inflammation and infections. Indeed, chronic inflammation orchestrates a tumor-supporting microenvironment that is an indispensable participant in the neoplastic process. The mechanisms that link infection, innate immunity, inflammation, and cancer are being unraveled at a fast pace. Important components in this linkage are the cytokines produced by activated innate immune cells that stimulate tumor growth and progression. In addition, soluble mediators produced by cancer cells recruit and activate inflammatory cells, which further stimulate tumor progression. However, inflammatory cells also produce cytokines that can limit tumor growth. Here we provide an overview of the current understanding of the role of inflammation-induced cytokines in tumor initiation, promotion, and progression.