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7062043 
Journal Article 
Inflammatory mechanism on obstructive sleep apnea syndrome in impacting ischemic stroke 
Lin, C; Yang, Y; , 
2017 
1 
Biomedical Research
ISSN: 0970-938X
EISSN: 0976-1683 
ALLIED ACAD 
LONDON 
28 
15 
6907-6910 
WOS:000412521200072 
Objective: To explore the inflammatory mechanism that Obstructive Sleep Apnea Syndrome (OSAS) impacts ischemic stroke.Methods: 100 patients admitted in department of neurology of our hospital were enrolled in the study and assigned into the cerebral ischemic stroke group without OSAS (control group, n= 50) and the cerebral ischemic stroke group with OSAS (observation group, n= 50). whose Apnea Hypopnea Index (AHI) and minimal arterial oxygen saturation (SaO(2) min) at night were detected and recorded by a multi-lead sleep monitor and whose hypersensitive C-Reactive Protein (Hs-CRP), Fibrinogen, (Fg), Nuclear Factor-kappa B (NF-kappa B), and Tumor Necrosis Factor (TNF-alpha) were tested by ELISA kits.Results: Compared with the control group, the AHI, Hs-CRP, Fg, NF-kappa B and TNF-alpha of the observation group increased significantly (p< 0.05, P< 0.01) but SaO(2) min decreased obviously (P< 0.05).Conclusion: OSAS is able to impact the occurrence of ischemic stroke but also aggravate it. The possible inflammatory mechanism is that it produces massive Hs-CRP by activating NF-kappa B/TNF-alpha signal pathway, then damages vascular endothelial function, and finally results in atherosclerosis and its development. 
Obstructive sleep apnea syndrome; Ischemic stroke; Inflammatory mechanism