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Citation
Tags
HERO ID
7063934
Reference Type
Journal Article
Title
Amaryllidaceae alkaloids with anti-Trypanosoma cruzi activity
Author(s)
Martinez-Peinado, N; Cortes-Serra, N; Torras-Claveria, L; Pinazo, MJ; Gascon, J; Bastida, J; Alonso-Padilla, J; ,
Year
2020
Is Peer Reviewed?
1
Journal
Parasites & Vectors
EISSN:
1756-3305
Publisher
BMC
Location
LONDON
PMID
32522289
DOI
10.1186/s13071-020-04171-6
Web of Science Id
WOS:000543360300004
Abstract
BackgroundChagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected disease that affects similar to 7 million people worldwide. Development of new drugs to treat the infection remains a priority since those currently available have frequent side effects and limited efficacy at the chronic stage. Natural products provide a pool of diversity structures to lead the chemical synthesis of novel molecules for this purpose. Herein we analyzed the anti-T. cruzi activity of nine alkaloids derived from plants of the family Amaryllidaceae.MethodsThe activity of each alkaloid was assessed by means of an anti-T. cruzi phenotypic assay. We further evaluated the compounds that inhibited parasite growth on two distinct cytotoxicity assays to discard those that were toxic to host cells and assure parasite selectivity.ResultsWe identified a single compound (hippeastrine) that was selectively active against the parasite yielding selectivity indexes of 12.7 and 35.2 against Vero and HepG2 cells, respectively. Moreover, it showed specific activity against the amastigote stage (IC50=3.31 mu M).ConclusionsResults reported here suggest that natural products are an interesting source of new compounds for the development of drugs against Chagas disease.
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