Lipman, J; Brett, SJ; De Waele, JJ; Cotta, MO; Davis, JS; Finfer, S; Glass, P; Knowles, S; Mcguinness, S; Myburgh, J; Paterson, DL; Peake, S; Rajbhandari, D; Rhodes, A; Roberts, JA; Shirwadkar, C; Starr, T; Taylor, C; Billot, L; Dulhunty, JM; ,
β-Lactam antibiotics display a time-dependent mechanism of action, with evidence suggesting improved outcomes when administering these drugs via continuous infusion compared with standard intermittent infusion. However, there is no phase 3 randomised controlled trial (RCT) evidence to support one method of administration over another in critically ill patients with sepsis.