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Citation
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HERO ID
7068913
Reference Type
Journal Article
Title
Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi
Author(s)
Aguilera-Venegas, B; Olea-Azar, C; Aran, VJ; Speisky, H; ,
Year
2013
Is Peer Reviewed?
Yes
Journal
Future Medicinal Chemistry
ISSN:
1756-8919
Publisher
FUTURE SCI LTD
Location
LONDON
Page Numbers
1843-1859
PMID
24144415
DOI
10.4155/FMC.13.144
Web of Science Id
WOS:000330725900013
Abstract
For years, Chagas disease treatment has been limited to only two drugs of highly questionable and controversial use (Nifurtimox (R) and Benznidazole (R)). In the search of effective drugs, many efforts have been made, but only a few structures have emerged as actual candidates. Heading into this, the multitarget-directed approach appears as the best choice. In this framework, indazoles were shown to be potent Trypanosoma cruzi growth inhibitors, being able to lead both the formation of reactive oxygen species and the inhibition of trypanothione reductase. Herein, we discuss the main structural factors that rule the anti-T. cruzi properties of indazoles, and how they would be involved in the biological properties as well as in the action mechanisms, attempting to make parallels between the old paradigms and current evidences in order to outline what could be the next steps to follow in regard to the future drug design for Chagas disease treatment.
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