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7075635 
Journal Article 
3D-printed PCL/bioglass (BGS-7) composite scaffolds with high toughness and cell-responses for bone tissue regeneration 
Kim, Y; Lim, JunY; Yang, GiH; Seo, JunH; Ryu, HS; Kim, G; , 
2019 
Yes 
Journal of Industrial and Engineering Chemistry
ISSN: 1226-086X 
ELSEVIER SCIENCE INC 
NEW YORK 
163-171 
WOS:000488135500017 
CaO-SiO2-P2O5-B2O3 bioglass (BGS-7) showed highly bioactive properties including osteoconductivity and good mechanical strength, but it has extremely brittle property. In this study, we developed a composite scaffold, which is incorporated into poly(epsilon-caprolactone)(PCL), to overcome the mechanical disadvantage of the bioglass scaffold. The composite scaffolds were fabricated with a microscale porous mesh structure using a 3D melt-printing process. Surface topographical images demonstrated that the bioglass particles were distributed homogeneously throughout the composite scaffolds. The mechanical properties (compression and three-point bending test) of the composite scaffolds showed the toughness of the composite scaffolds was significantly improved compared to that of the pure bioglass scaffold with a similar porosity. We characterized the in vitro biological properties of the pure PCL, BGS-7, and composite scaffolds using MC3T3-E1 cells. As the weight fraction of bioglass increased, the cell proliferation and osteogenic activities significantly increased owing to the enhanced hydrophilic property, protein absorption, and precipitation of calcium phosphate from the bioglass. However, for the high weight fraction of bioglass (60 wt%) in the composite scaffold, the toughness was significantly lower than that of the composite scaffold (40 wt%). Based on these results, the appropriate concentration (40%) of the BGS-7 in the composite showed meaningful bioactivities and toughness. (C) 2019 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.