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7078639 
Journal Article 
Effect of methylene blue on human nasal allergy 
Yajin, K; Watanabe, H; Kawamoto, H; Koro, O; Nakata, M; , 
1996 
MONDUZZI EDITORE 
40128 BOLOGNA 
7-10 
WOS:A1996BH77A00002 
The involvement of nitric oxide (NO) in the pathogenesis of nasal allergy has been reported in recent years. It is known that the effect of NO is mediated mainly by activation of guanylate cyclase (GC) and it is also known that methylene blue (MB) inhibits the activity of GC. In our clinical study,MB inhibits antigen-induced sneeze and rhinorrhea. In this study, we investigated the effect of MB on antigen-induced release of histamine and leukotrienes (LTs) from human nasal polyp in vitro. MB inhibited the release of LTB4, while it did not inhibit the release of histamine and LTC4/D-4/E-4. 
McCafferty, G; Coman, W; Carroll, R; 
88-323-0302-7 
XVI World Congress of Otorhinolaryngology Head and Neck Surgery (SYDNEY 97) 
SYDNEY, AUSTRALIA