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7083554 
Journal Article 
Synthesis of Hydrazone Derivatives of 4-[4-Formyl-3-(2-oxochromen-3-yl)pyrazol-1-yl]benzoic acid as Potent Growth Inhibitors of Antibiotic-resistant Staphylococcus aureus and Acinetobacter baumannii 
Whitt, J; Duke, C; Sumlin, A; Chambers, SA; Alnufaie, R; Gilmore, D; Fite, T; Basnakian, AG; Alam, MA; , 
2019 
1 
Molecules
ISSN: 1420-3049 
MDPI 
BASEL 
24 
11 
English 
31146470 
WOS:000472631000024 
Microbial resistance to drugs is an unresolved global concern, which is present in every country. Developing new antibiotics is one of the guidelines of the Centers for Disease Control and Preventions (CDC) to combat bacterial resistance to drugs. Based on our lead molecules, we report the synthesis and antimicrobial studies of 27 new pyrazole derivatives. These new coumarin-pyrazole-hydrazone hybrids are readily synthesized from commercially available starting materials and reagents using benign reaction conditions. All the synthesized molecules were tested against 14 Gram-positive and Gram-negative bacterial strains. Several of these molecules have been found to be potent growth inhibitors of several strains of these tested bacteria with minimum inhibitory concentrations as low as 1.56 g/mL. Furthermore, active molecules are non-toxic in in vitro and in vivo toxicity studies.