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7088971 
Journal Article 
Neurodevelopmental outcome in prenatally diagnosed isolated agenesis of the corpus callosum 
Folliot-Le Doussal, L; Chadie, A; Brasseur-Daudruy, M; Verspyck, E; Saugier-Veber, P; Marret, S; , 
2018 
Yes 
Early Human Development
ISSN: 0378-3782
EISSN: 1872-6232 
ELSEVIER IRELAND LTD 
CLARE 
116 
9-16 
English 
29091783 
WOS:000426235000002 
Neurodevelopmental outcome in children with agenesis of the corpus callosum (ACC) is correlated with the presence or absence of associated brain abnormalities. Indeed, neurodevelopmental outcome shows severe disabilities when the ACC is not isolated whereas in isolated forms, the neurologic development is mainly normal. Contrary to data in several published studies, the prognosis remains uncertain even in isolated forms, which may lead in France to medical termination of pregnancy.Objective: To evaluate long-term neurodevelopmental outcome in children with prenatally diagnosed isolated ACC.Design, setting and participants.This is a follow-up study conducted in Normandy (France). It included a cohort of 25 children born between January 1991 and June 2016, with a prenatal diagnosis of isolated ACC and who were followed for at least two years.Results: The average follow-up was 8 5 years. ACC was complete in 17 patients (68%), partial in 5 (20%) and hypoplastic in 3 (12%). Whereas global motor development was normal in each case, normal neurodevelopmental outcome or mild disabilities occurred in 88% children and moderate/severe neuro-disabilities were present in 12% of children. Wechsler Intelligence Scale for Children-IV evaluations and Intellectual Total Quotients were within normal range, but we observed lower scores in verbal comprehension, social judgment, executive functions. A lower score in morphosyntax was observed among 52% of children with oral language disorders.Conclusions: Neurodevelopmental outcome was favorable in most of our patients with isolated ACC, but mild learning disabilities emerged in older children. Long-term follow-up until school age is essential to provide early diagnosis and appropriate care support. 
Agenesis of the corpus callosum; Prenatal diagnosis; Cognitive development; Neurodevelopmental outcome