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HERO ID
7093515
Reference Type
Journal Article
Title
Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits
Author(s)
Alcayaga, J; Del Rio, R; Moya, EA; Freire, M; Iturriaga, R; ,
Year
2018
Is Peer Reviewed?
Yes
Journal
Biological Research
ISSN:
0716-9760
EISSN:
0717-6287
Publisher
SOC BIOLGIA CHILE
Location
SANTIAGO
Volume
51
Issue
1
Page Numbers
57
Language
English
PMID
30572940
DOI
10.1186/s40659-018-0207-2
Web of Science Id
WOS:000453897600001
Abstract
Background: chronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it's impact on heart rate variability and autonomic regulation have been less well examined. We studied changes in arterial blood pressure, heart rate and heart rate variability (HRV) in rabbits subjected to chronic normobaric hypoxia (CNH; PB similar to 719 mmHg;-FIO2 similar to 9.2%) for 14 days and assess the effect of autonomic control by acute bilateral vagal denervation.Results: exposure to CNH stalled animal weight gain and increased the hematocrit, without affecting heart rate or arterial blood pressure. Nevertheless, Poincare plots of the electrocardiographic R-R intervals showed a reduced distribution parallel to the line of identity, which interpreted as reduced long-term HRV. In the frequency domain, CNH reduced the very-low-(< 0.2 Hz) and high-frequency components (> 0.8 Hz) of the R-R spectrograms and produced a prominent component in the low-frequency component (0.2-0.5 Hz) of the power spectrum. In control and CNH exposed rabbits, bilateral vagotomy had no apparent effect on the short-and long-term HRV in the Poincare plots. However, bilateral vagotomy differentially affected higher-frequency components (> 0.8 Hz); reducing it in control animals without modifying it in CNH-exposed rabbits.Conclusions: These results suggest that CNH exposure shifts the autonomic balance of heart rate towards a sympathetic predominance without modifying resting heart rate or arterial blood pressure.
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