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7097621 
Journal Article 
Multi-Omics Research Trends in Sepsis: A Bibliometric, Comparative Analysis Between the United States, the European Union 28 Member States, and China 
Evangelatos, N; Satyamoorthy, K; Levidou, G; Bauer, Pia; Brand, H; Kouskouti, C; Lehrach, H; Brand, A; , 
2018 
1 
O M I C S: A Journal of Integrative Biology
ISSN: 1536-2310 
MARY ANN LIEBERT, INC 
NEW ROCHELLE 
190-197 
29649387 
WOS:000430017200003 
-Omics research is in transition with the recent rise of multi-omics technology platforms. Integration of -omics and multi-omics research is of high priority in sepsis, a heterogeneous syndrome that is widely recognized as a global health burden and a priority biomedical funding field. We report here an original study on bibliometric trends in the use of -omics technologies, and multi-omics approaches in particular, in sepsis research in three (supra)national settings, the United States, the European Union 28 Member States (EU-28), and China. Using a 5-year longitudinal bibliometric study design from 2011 to 2015, we analyzed the sepsis-related research articles in English language that included at least one or multi-omics technologies in publicly available form in Medline (free full texts). We found that the United States has had the lead (almost one-third of publications) in the inclusion of an -omics or multi-omics technology in sepsis within the study period. However, both China and the EU-28 displayed a significant increase in the number of publications that employed one or more types of -omics research (p<0.005), while the EU-28 displayed a significant increase especially in multi-omics research articles in sepsis (p<0.05). Notably, more than half of the multi-omics research studies in the sepsis knowledge domain had a university or government/state funding source. Among the multi-omics research publications in sepsis, the combination of genomics and transcriptomics was the most frequent (40.5%), followed by genomics and proteomics (20.4%). We suggest that the lead of the United States in the field of -omics and multi-omics research in sepsis is likely at stake, with both the EU-28 and China rapidly increasing their research capacity. Moreover, triple omics that combine genomics, proteomics, and metabolomics analyses appear to be uncommon in sepsis, and yet much needed for triangulation of systems science data. These observations have implications for -omics technology policy and global research funding strategic foresight.