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7099744 
Journal Article 
IRESpy: an XGBoost model for prediction of internal ribosome entry sites 
Wang, J; Gribskov, M; , 
2019 
1 
BMC Bioinformatics
EISSN: 1471-2105 
BMC 
LONDON 
English 
31362694 
WOS:000477931800002 
Internal ribosome entry sites (IRES) are segments of mRNA found in untranslated regions that can recruit the ribosome and initiate translation independently of the 5' cap-dependent translation initiation mechanism. IRES usually function when 5' cap-dependent translation initiation has been blocked or repressed. They have been widely found to play important roles in viral infections and cellular processes. However, a limited number of confirmed IRES have been reported due to the requirement for highly labor intensive, slow, and low efficiency laboratory experiments. Bioinformatics tools have been developed, but there is no reliable online tool.