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7100781 
Journal Article 
Penile malakoplakia associated with lichen sclerosus 
Amsellem, J; Corgibet, F; Ponnelle, T; Dauendorffer, JN; , 
2019 
Yes 
Annales de Dermatologie et de Venereologie
ISSN: 0151-9638
EISSN: 2214-5451 
MASSON EDITEUR 
MOULINEAUX CEDEX 9 
812-816 
31627929 
WOS:000506200100007 
Introduction. - Malakoplakia is a granulomatosis of infectious origin in reaction to a chronic bacterial infection (most commonly urinary Escherichia colt) related to an acquired phagocytosis impairment.Patients and methods. - We report a case of penile malakoplakia in a 69-year-old man with lichen sclerosis and stenosis of the urinary meatus leading to recurrent urinary tract infections. The clinical aspect was suggestive of squamous cell carcinoma of the glans developing on lichen sclerosus, but histological examination revealed penile nnalakoplakia.Discussion. - Malakoplakia of the genital mucosa is rare, with only one case of involvement of the glans being reported in the literature. The association with lichen sclerosus is probably not fortuitous but could in fact be due to chronic urinary tract infection favored by stenosis of the urethral meatus and possible local immunodepression following prolonged application of clobetasol.Conclusion. - We report a case of penile nnalakoplakia associated with chronic E. coil urinary tract infection, due originally to associated genital lichen sclerosus. (C) 2019 Published by Elsevier Masson SAS.