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7103176 
Journal Article 
Simulated Moving Bed Chromatography: From Concept to Proof-of-Concept 
Gomes, PSa; Rodrigues, AE; , 
2012 
Yes 
Chemical Engineering and Technology
ISSN: 0930-7516
EISSN: 1521-4125 
WILEY-BLACKWELL 
MALDEN 
35 
1 
17-34 
WOS:000298540200003 
This work presents a comprehensive insight about simulated moving bed (SMB) technology, from concept to unit operation and process demonstration. A particular relevance is given to SMB nonconventional modes of operation, modeling, and design of SMB-based separations as well as to the construction and operation of SMB units. A conventional separation of a racemic mixture of (S,R)-a-tetralol by means of the FlexSMB-LSRE (R) unit is addressed to better exemplify a state-of-the-art SMB lab-scale process development and demonstration. 
Chiral resolution; Chiralpak (R) AD; Continuous chromatographic processes; Countercurrent moving bed chromatography; Enantiomer separation; Simulated moving bed; True moving bed 
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