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7103336 
Journal Article 
Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes 
Winters, MP; Bell, A; Clapper, W; Jenkinson, C; Haug, P; Koudriakova, T; Huebert, N; Murray, WV; Sui, Z; Wall, M; Wang, Y; Gunnet, J; Leonard, J; Hua, H; Yan, Wen; Suckow, A; , 
2018 
Yes 
Bioorganic & Medicinal Chemistry Letters
ISSN: 0960-894X
EISSN: 1464-3405 
PERGAMON-ELSEVIER SCIENCE LTD 
OXFORD 
841-846 
29456108 
WOS:000426598500001 
The discovery of a novel series of N-arylpyrroles as agonists of GPR120 (FFAR4) is discussed. One lead compound is a potent GPR120 agonist, has good selectivity for related receptor GPR40 (FFAR1), has acceptable PK properties, and is active in 2 models of Type 2 Diabetes in mice. (C) 2018 Elsevier Ltd. All rights reserved.